Abstract
Armand Trousseau is credited with describing the first paraneoplastic syndrome in 1865. He concluded through careful probabilistic reasoning that the association of migratory thrombophlebitis with the discovery of occult malignancy was more than coincidental. Dozens of paraneoplastic syndromes have been recognized since then and the pathogenesis of many are reasonably well understood. The syndromes can be divided into two general categories based on whether the remote effect of cancer is mediated through a peptide, protein or prostaglandin or through an immunoglobulin. This chapter will describe the seminal studies surrounding two ocular paraneoplastic syndromes: bilateral diffuse uveal melanocytic proliferation and cancer-associated retinopathy. The photograph gallery includes examples of the pathology of bilateral diffuse melanocytic proliferation and cancer-associated retinopathy.
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