Abstract
The field of spinal cord injury (SCI) research has experienced an immense evolution over the past decades whereby results from preclinical studies have significantly facilitated our understanding of pathophysiologic mechanisms underlying SCI, including causes of heterogeneity in outcomes among patients. Notably, in detail knowledge of the pathobiology in SCI will guide us in identifying therapeutic targets and personalizing SCI management. A multitude of exciting preclinical studies are at the edge of translation into clinical trials. However, designing future clinical trials and translational research strategies requires consideration of several key factors. In this chapter, we will discuss the key concepts that need future consideration when translating from preclinical models to clinical trials and provide an overview of promising future directions in translational SCI research.
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