Abstract
Regenerative Medicine is a discipline that aims at reinstating physical and functional integrity of a damaged organ via rejuvenation with endogenous stem cells, replacement with bioengineered tissues, and regeneration with transplantation of exogenous stem cells. In the case of the heart, the possibility of replacing dysfunctional myocardium with de novo tissue offers a curative approach to augment traditional management strategies to prevent disease progression toward heart failure. Across a broad range of acquired and/or congenital cardiac diseases, regenerative strategies are being optimized for individual patients with the goal of providing disruptive technology that aims to transform therapeutic outcomes and reduce the overall expenditure required for life-long disease management. Developmental biology provides a firm foundation to accelerate stem cell technologies toward cardiac clinical applications for transplant medicine and surgery.
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