Chapter 3 - Asymmetric transformations under cobalt catalysis

Abstract

Cobalt catalysis is a powerful alternative to precious metal catalysis with regard to various organic reactions owing to its earth abundance, low cost, and low toxicity. This study focuses on asymmetric cobalt catalysis with chiral phosphine ligands, which includes allylic substitutions, cycloaddition and cyclization, hydroalkynylation, C–H functionalization, hydroboration, hydrogenation, and hydrovinylation. Mechanistic considerations of these cobalt-catalyzed asymmetric reactions are also discussed.