Abstract
The emergence and re-emergence of life-threatening infectious diseases and health ailments demand newer drug screening strategies. Novel drug discovery and screening strategies require comprehensive knowledge of the underlying molecular mechanisms that partake in disease metabolism and regulation and in-depth insight into the genomes of disease-causing microbes. For this, representative disease models are needed along with the advanced and integrated biological and computational screening approaches to accelerate the drug discovery process. In the past few decades, efforts have been made to boost the process of novel drug discovery for clinical application with no significant success in the field. In this chapter, several aspects of available biological screening methodologies have been discussed in detail along with their advantages and limitations. Meticulous selection and implementation of these methodologies and approaches either individually or in combination have the potential to boost the process of drug discovery and development.
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