Abstract
Abstract This chapter describes the theoretical fundamentals of capillary electrochromatography and gives an insight on the formation and characteristics of the electroosmotic flow and the respective factors to optimize retention. In electro-driven separations, greater efficiencies can be achieved compared to pressure-driven separations in liquid chromatography. Instrument setup and examples of hardware configurations are presented, and separation efficiency and kinetic performance limits are discussed. Finally, different column technologies and stationary-phase chemistry developments used to optimize separation efficiency and selectivity are described, and an overview of selected recent state-of-the-art applications is highlighted, focussing on biochemical and biopharmaceutical analysis, small molecule pharmaceuticals and enantiomer separations.
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