Abstract
The male accessory sex glands derive from the mesonephric duct (ampullary glands and seminal vesicles) or the urogenital sinus (prostate gland, coagulating glands, and bulbourethral glands). These tissues are responsive to androgens (particularly dihydrotestosterone) and as such, are valuable indicators of hormonal influences including compounds affecting the hypothalamic–pituitary–gonadal axis, androgen receptors, and enzymes of androgen metabolism. For rats, neoplasms of these tissues are uncommon to rare among the strains routinely used in toxicologic assessments. However, certain strains serve as useful models for human disease processes. This chapter describes the commonly observed spontaneous nonneoplastic and neoplastic changes of the male accessory sex glands and compound-related effects.
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