Abstract
This chapter focuses on what has been learned by analyzing mice bearing specific alterations in the intracellular signaling domains of the two PDGFRs. Highly defined characterization of the biochemical and cellular functions of platelet-derived growth factors(PDGFs) and their receptors (PDGFRs), set the stage to use this system as a genetic model to study receptor tyrosine kinase (RTK) signaling in mammalian development. Following binding to PDGF, PDGFRs autophosphorylate, enabling them to bind and then activate intracellular proteins that relay the receptor's signals throughout the cell. PDGF stimulates cellular functions including mitogenesis, survival, and chemotaxis. Several features of the PDGFR system make it an appropriate model to investigate whether specific signals transmitted by RTKs translate into unique physiological functions in vivo.
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