Abstract
The use of liquid chromatography high–resolution mass spectrometry (LC–HRMS) and direct analysis real-time high-resolution mass spectrometry (DART–HRMS) defines a new scenario in the analysis of thermal-induced toxicants, such as acrylamide. Several factors contribute to the definition of the complex network related to the acrylamide detection—high polarity, low molecular weight, and matrix effects. In this respect, LC–HRMS offers some advantages such as high reproducibility, low relative standard deviation, and high mass accuracy. In addition, DART approach is able to combine chemometric tools and analytical chemistry. A general overview on the pros and cons related to acrylamide detection by HRMS is provided focusing on the relationship between predictive, indirect, and targeted analysis. Both techniques are compared with the golden standards for acrylamide detection to get more insights into the proper analytical strategy for its quantification.
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