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Abstract
Publisher Summary This chapter discusses the pharmacology of putative neurotransmitters and receptors—that is, 5-hydroxytryptamine (5HT). The systems that contain 5HT alter the responses of many species to high-threshold cutaneous stimuli. If neurons in the brain that contain 5HT are destroyed with the selectively neurotoxic compound 5,7-dihydroxytryptamine, the antinociceptive effects of morphine are strongly attenuated. Depletion of 5HT from the central neurons with parachlorophenylalanine will also reduce the antinociceptive effects of (a) systemic morphine, (b) periaqueductal gray (PAG) stimulation, and (c) nucleus raphe magnus (NRM) stimulation. The serotonergic raphe-spinal neurons are important because (1) lesions of the NRM reduce the antinociceptive effects of systemic morphine, (2) excitation of NRM cells causes antinociception, (3) intrathecal administration of 5HT causes antinociception, and (4) microiontophoretic application of 5HT mimics the antinociceptive effects of NRM stimulation.
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