Abstract
Addenbrooke's Cognitive Examination (ACE) is a brief cognitive test validated in several languages and settings for the screening and differential diagnosis of dementia. ACE provides a total score and five additional scores (attention/orientation, memory, verbal fluency, language, and visuospatial abilities). The test is influenced by demographic factors and, thus, the use of normative data is recommended. ACE plays a dual role in cognitive assessment, serving as a screening tool, as well as a brief neuropsychological battery. Several studies have validated its use for the diagnosis of dementia, mild cognitive impairment, Alzheimer's disease, other dementias (primary progressive aphasia and behavioral variant frontotemporal dementia), cognitive impairment associated with Parkinson's disease, atypical parkinsonisms, and vascular cognitive impairment, among others.
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