Abstract
Publisher Summary The analysis of the involvement of the efferent sympathetic system in the control of thermally induced and febrile thermoregulatory adjustments has to consider its property to produce regionally non-uniform changes of activity, which has been termed as “regional sympathetic differentiation.” Depending on the kind of stimulation, different patterns of regional differentiation may be elicited. In this chapter the patterns displayed in the state of fever are addressed to elucidate the contribution of this response type of sympathetic innervation to the thermoregulatory vasomotor adjustments, as well as to non-thermal factors in the general defence response of the fever syndrome. In the assessment of the phenomenon of regional sympathetic differentiation, the use of anesthesia as an experimental tool is being replaced by procedures in which animals are equipped with chronically implanted recording electrodes. A number of studies exist on conscious cats with chronically implanted recording electrodes in which the responses of regional sympathetic activity to various stimuli, such as blood pressure changes, coronary occlusion and static exercise, are analyzed.
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