Abstract
Direct transport of medications from the nose to the brain via olfactory and trigeminal nerve pathways bypassing the blood-brain barrier (BBB) has gained great attention for efficient delivery of broad range of neurotherapeutics. Over the last several decades, researchers have explored different novel drug delivery systems (NDDSs), viz. nanoparticles, liposomes, polymeric micelles, and nanoemulsions for targeting the brain through intranasal drug administration. Following intranasal application, the estimation of drugs in the brain is an important consideration for assessing the efficacy of direct nose-to-brain drug transport. The brain drug concentrations following intranasal administration can be estimated both qualitatively as well as quantitatively. In addition, the calculation of intranasal drug dose in relation to oral human dose is also an important aspect one should know before execution of any preclinical and/or clinical research experiment. The major goal of the present chapter is to bring into focus the different qualitative and quantitative drug analysis techniques, precise dose calculation, and translational compartment modeling for the readers and researchers.
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