Abstract
Publisher Summary This chapter describes the cerebral hemodynamics in the human newborn studied by an electrical impedance method. The ability to study the cerebral circulation of newborn babies at risk of developing brain damage is increasing in importance. The evaluation of this technique to study cerebral blood flow (CBF) in newborn babies has had several distinct phases. A significant correlation was found when limb blood flow in babies, as estimated by a strain gauge method, was compared with the amplitude of a simultaneously recorded impedance signal. A mathematical model was developed to describe the distribution of the electrical current through the neonatal head. In the third stage of the development of this method, the electrical impedance signals were compared with estimates of CBF made by strain gauge plethysmography in individual term babies. CBF was altered by administration of 2% carbon dioxide and 100% oxygen. In all five studies in which the baby was known to have received a steady concentration of carbon dioxide, increased CBF as indicated by strain gauge measurements and an increase in the amplitude of the electrical impedance signal, were seen and in six of seven studies using 100% oxygen, a decrease in these variables was seen suggesting reduced CBF.
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