Abstract
Publisher Summary This chapter discusses the synthesis and assembly of transmembrane viral and cellular glycoproteins, including transmembrane biosynthesis of the vesicular stomatitis virus (VSV) glyco (G) protein. VSV encodes five polypeptides, all of which are structural components of the virions, and directs the synthesis of five corresponding messenger ribonucleic acid (mRNA) species. A VSV particle, like those of most lipid-containing animal viruses, is formed by budding from the plasma membrane of an infected cell. The chapter discusses the biogenesis of two sindbis virus G proteins. Sindbis, like VSV, is a lipid-enveloped virus; however, it contains only three structural proteins, two of which are envelope G proteins—that is, integral membrane proteins (E 1 and E 2 ). The interaction of nascent Sindbis glycoprotein and the endoplasmic reticulum and the movement of transmembrane viral glycoproteins from the rough endoplasmic reticulum to the plasma membrane are described in the chapter.
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