Abstract
Targeted and controlled drug delivery systems are widely utilized nowadays to deliver drugs for the treatment of various diseases. A targeted drug delivery system in biomedicals essentially deals with polymer–drug conjugates (PDCs), which have superior effects in terms of bioavailability, reduced toxicity, and biocompatibility, when compared to traditional drug delivery systems. The most important component in the production of the PDC is a linker, which is responsible for joining two molecules and releasing the active molecule at the target location in response to external and internal stimuli. This chapter discusses the rational design of linkers in PDCs, followed by a study of the various classes of linkers involved in polymer conjugates.
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