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Abstract
This chapter reviews the use of microfiltration membranes in the pharmaceutical and biotechnology industries as well as recent advances in microfiltration processes. Applications include cell harvesting and concentration, product separation from cell debris, and microbe and virus removal. Microfiltration technologies include both deadend and crossflow geometries, as well as methods for fouling control. Recent advances in alternating tangential-flow filtration, continuous processing, and single-use disposable technologies are highlighted. These new advances may lead to increased use of microfiltration for cell harvesting and primary product separation, which have largely relied on centrifugation and depth filtration in recent years.
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