Chapter 2 - Mechanisms of antibacterial drug resistance and approaches to overcome

Abstract

In this chapter, we discuss the global threat imposed by the emergence of multidrug-resistant (MDR) bacterial strains and what we can do to mitigate this growing danger. To deal with the growing threat of MDR strains, we need to reduce the worldwide misuse of antibiotics both in human and in veterinary medicine. In addition, we have to speed up the pipeline for developing new antibiotics. To achieve that, we may need to use novel mechanisms of drug action, drug delivery, and employ novel antibacterial drug targets. In the present review, we have discussed the mode of actions of antibacterial drugs and the process by which resistance is developed and propagated. Moreover, we have also highlighted those MDR strains that need to be addressed urgently by using alternate antibiotics with unique mechanisms.