Abstract
This chapter reviews the methodologies utilized to investigate [ 3 H]strychnine binding within the central nervous systems of a variety of vertebrate species. [ 3 H]strychnine binding has been associated with central glycine receptors. The site on the receptor complex to which strychnine binds is probably not the glycine recognition site but a site more closely associated with the ionic conductance mechanism. The site to which strychnine binds is the site with which a variety of strychnine analogs, opiate alkaloids, and certain other convulsants interact. It is conceivable that strychnine binding sites may also be associated with inhibitory effects of substances, such as taurine and/or β -alanine in brain. Abnormalities in [ 3 H]strychnine binding have been found in rodent genetic disorders and human motor neuron disease. In the future, it may be possible to develop a suitable ligand for the agonist binding site, independently isolate the various receptor subunits, and develop the type of information about the glycine receptor that has been gathered for the nicotinic cholinergic receptor.
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