Abstract
Targeting drug delivery toward deeply seated cancer cells is very difficult, due to the limited effectiveness of anticancer drugs and wider side effects. This chapter reviews the potential remedy to the issue, that is, nanoengineered mesenchymal stem cells (MSCs) for cancer targeting. Nanoengineered MSCs are generally formulated by curing human MSCs with drug-loaded nanoparticles (NPs). MSCs have a tumor homing capacity and reduce cancer cell drug resistance, making them ideal carriers for anticancer drugs. The incorporation of NPs into MSCs has no effect on cell viability, differentiation, or migration. Nanoengineered MSCs have a targeted delivery capacity and can provide a dose-dependent anticancer effect. NPs containing anticancer drugs have more side effects and less efficacy than nanoengineered MSCs containing the same drug. Hence, MSCs can be applied as future carriers for cancer targeting.
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