Abstract
The chapter reanalyzes the influence of the degree of heterogeneity along with the effect of diffusional limitations on the binding kinetics of soluble rabbit IgG/rSpA (recombinant protein) on a surface-based biosensor. The chapter attempts to uncouple the effect of external mass transfer limitations from the degree of heterogeneity present on the surface on the biosensor performance parameters, using a fractal analysis. The application of biosensors in the areas of biotechnology, environment, medical diagnostics, and security applications is described in the chapter. The fractal analysis explains the binding of soluble rabbit IgG in solution to recombinant protein A immobilized on a straight-microchannel- and serpentine-microchannel-surface-based biosensors. The influence of Reynolds number on the binding rate coefficient for both the straight-channel- and the serpentine-channel-based biosensor is presented in the chapter.
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