Abstract
Rabies is a rapidly progressive infection of the central nervous system. It usually is spread when virus-laden saliva enters through a break in the skin, typically via a bite from a rabid animal. Stages of rabies include incubation period, prodromal period, acute neurologic period, coma, and death. The incubation period has a notable variation in length. There are numerous clinical signs in animals; common ones are unexplained paralysis and a change in behavior. Clinical signs and symptoms in humans are many and varied as are differential diagnoses of encephalitis, myelitis, or encephalomyelitis. Exposures to animals, intermittent signs and symptoms of agitation, hydrophobia, aerophobia, and autonomic dysfunction, along with dysesthesia or myoclonus referable to the bitten limb and rapid worsening of neurologic signs, are some positive indicators for rabies.
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