Abstract
Regenerative engineering seeks to address the most complex and relevant questions in the realm of future of regeneration, namely, how to regenerate complex structures comprised of multiple types of tissues including organized structures to improve the quality of life and the scope of structural and biological ailments that can be treated by modern biomedical science. This challenge requires a paradigm shift that incorporates a transdisciplinary approach. To reproducibly regenerate complex tissue and organ systems, a regenerative engineer must use tools from many traditional fields of study including advanced materials science, stem cell science, physics, and developmental biology, as well as observations and applications from medicine and surgery. The regenerative capability of the adult human body is surprisingly very high, and modern regenerative engineering can harness this potential to slow, halt, or even reverse the effects of injury, infection, cancer, and age-related degradation. This chapter highlights the scope of work in the field of regenerative engineering, including the development of novel materials, recent scientific breakthroughs, future research directions, as well as the potential impact regenerative engineering can have on the practice of orthopedic surgery and the ability for the orthopedic surgeon to innovate in the future.
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