Abstract

This chapter discusses the proteomics of the venom of the parasitoid nasonia virtipennis. Nasonia vitripennis is an ectoparasitoid that uses host flies as a food source for its progeny, whereby the venom of adult females is used to subdue the host. The venom of this tiny wasp is able to elicit several host responses ranging from an altered immunity to developmental changes. Over the last few years, the proteomic research of venomous substances has gained more and more interest and several powerful tools have become available. Animal venoms contain a complex mixture of proteins, enzymes, peptides, and small organic compounds. Venomics, the analysis of venom proteomes, has gained a lot of interest because venoms are used for predation or defense and contain toxic compounds that are associated with specific pathologies. Identification of venom components in parasitoid wasps was restricted due to the technological limitations and lack of genome sequences.

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