Abstract
Publisher Summary This chapter compares new findings from studies of cell transplantation in a rat contusion model with those utilizing a complete transection/cellular bridge paradigm. In both cases, Schwann cells (SCs) support substantial axonal regeneration and myelination in the graft. In neither case, brainstem or cortical axons appear to enter the graft. Studying transplantation in a contusion model is clinically relevant; however, there is the challenge of distinguishing spared and sprouted fibers from fibers that have regenerated. Therefore, the chapter uses a complete transection model to obtain unambiguous results by placing a cellular bridge between the stumps of completely transected adult Fischer rat thoracic spinal cord.
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