Abstract
Trace amines (TAs) are biogenic amines located in mammalian brains and peripheral nervous tissues in low concentrations. Examples of TAs include phenylethylamine, tyramine, tryptamine, and octopamine, all of which are closely related to dopamine, norepinephrine, and serotonin neurotransmitter systems metabolically. Understanding the role of TAs in the progression of neuropsychiatric disorders is important for elucidating the pathway(s) and mechanism(s) leading up to the management of such disorders. Recently, TAs have been implicated in various neuropsychiatric disorders such as, depression, schizophrenia, attention deficit hyperactivity disorder, Parkinson disease, Alzheimer disease, Reye syndrome, Tourette syndrome, epilepsy, and migraines. The neuropsychiatric disorders and the associated psychotropic drugs, coupled with the possibility of the elucidation of the newer pathways have been explored in this chapter along with highlighting the recent advances in the area of TAs chemistry and synaptic physiology and their interrelationships.
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