Abstract
This chapter introduces amorphous solid dispersions and their use in solid oral dosage forms during drug development. It begins by defining the components in a dispersion and outlining advantages and disadvantages of the dispersions. It then covers physical characterization techniques used to analyze the materials as well as screening and selection methodology to help find a dispersion with the best properties, such as physical stability and solubility. Three main methods of scale-up (melt extrusion, spray drying, and fluid granulation) will be discussed. The chapter ends with information on formulating the dispersions into solid oral dosage forms. Case studies of marketed products will be included.
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