Abstract
This chapter reports the results of [18F]fluorodopa studies performed in two normal volunteers in both tomographic (2D) and volumetric (3D) acquisition modes. The quantitation of 3D acquisitions has been compared with that of 2D acquisitions. In the 3D mode, the [18F]fluorodopa uptake in the striata is measured without scatter correction and with the estimation of true method (ETM) for scatter correction. The study is conducted on an ECAT 953B under different statistical conditions. For each subject, a MRI scan from a 0.5 T imager is used for 3D registration with the positron emission tomography images obtained in 2D and in 3D modes. Regions of interest (ROIs) were defined on the MRI and then reported on the corresponding PET images so that ROIs at the same anatomical location are used for the comparison of the 2D and 3D modes. The 3D mode without scatter correction leads to an underestimation of the [18F]-fluorodopa uptake in the striata when compared with the 2D mode. The ETM scatter correction helps recover more quantitative values of the tracer uptake in the striata. This study also brings some insights into the strategy for the ROI analysis in 3D: the parameter estimation for such small structures seems to be more sensitive to the ROI type in 3D than in 2D.
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