Abstract
This chapter discusses the hormonal regulation of cellular energy metabolism. Hormones modulate metabolic flows to integrate the functioning of different cells and tissues, and to optimize the use of available resources. One of their important tasks is regulating the distribution of energy utilization to accommodate the variations in demand for energy, and regulating the supply of fuel to meet these demands. Organisms can handle large fluctuations in the flux through substrate supply or energy utilization reactions, while maintaining homeostatic control over important metabolic intermediates. Although the advantages to the organism of maintaining homeostatic control are evident, the mechanisms by which this occurs, or by which it is adjusted to changing metabolic needs in the cell, are not yet well understood. Hormones are external regulators of cellular metabolism that make use of the internal control mechanisms of oxidative phosphorylation to adapt energy supplying reactions to the needs of the organism.
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