Abstract
The field of tissue engineering (TE) has currently invested in advanced approaches for the regeneration and reconstruction of damaged or diseased tissues, such as bone, cartilage, skin, tendon, and many others. Biocomposite hydrogels are relevant tissue-like matrices that aim to improve the mechanical strength, swelling capability, and encapsulation efficacy, in order to afford the necessary biochemical cues for functionally engineered tissues, that the single components cannot attain. In this sense, the benefits of combining natural and synthetic biopolymers incorporating inorganic biomaterials become evident to form hydrogels with enhanced and desirable properties for a wide range of applications, mainly for TE, wound dressing, and systems for drug delivery. A comprehensive summary of the latest biocomposite hydrogels as scaffolds containing natural and/or synthetic biopolymers combined with inorganic fillers are herein presented. Their structure, design, customized mechanical performance and applications in tissue repair and regeneration are highlighted.
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