Abstract
In an Atherosclerosis Risk in Communities study involving 12,881 patients, whole blood viscosity (WBV) calculated according to a validated mathematical formula (estimated WBV) at shear rate of 208/s1 was found to be positively correlated with high body mass index, waist circumference, waist:hip ratio, systolic blood pressure, fasting plasma glucose level, serum insulin level, plasma fibrinogen level, white blood cell count, and serum triglyceride levels, and it was inversely associated with serum HDL cholesterol levels. Diabetes myelitis was positively associated with WBV. Plasma viscosity and fibrinogen levels were shown to be associated with cardiovascular disease. Alzheimer’s disease (AD) subjects compared to controls had significantly higher WBV. High fibrinogen levels were associated with an increased risk of both AD and vascular dementia. In reserpine-treated rats, the different BA like 5-HT, tryptamine, tyramine and epinephrine at low doses elevated (~twofold) plasma fibrinogen level. Overall, tryptamine and its metabolite DMT implicate in the blood viscosity changes related to different pathologies including AD. Altered hemorheology can be a predictor factor in cardiovascular disease development.
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