Abstract
Cancer, one of the world's leading causes of death, is a collection of diseases characterized by the uncontrolled growth and spread of abnormal cells. To date, 58 Receptor Tyrosine Kinases (RTKs) have been identified in the human genome, which regulates a broad range of cellular processes, including cell survival, growth, differentiation, proliferation, adhesion, and motility that play an essential role in the treatment of cancer. The TAM receptors (TYRO3, AXL, and MERTK) are a well-studied family of tyrosine kinase receptors that, in addition to their function in many other cell types, including cancer cells, play essential roles in macrophage, polarization, and efferocytosis. Natural products have been identified as promising sources of drugs for the treatment and prevention of cancer in recent years. The current chapter focuses on the virtual screening of natural products derived from the different databases on the TAM subfamily of RTK inhibitors to find novel drug molecules for cancer treatment.
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