Abstract
Cell division in the majority of eukaryotes occurs by an open mitosis, which includes, among other processes, the disassembly of the nuclear envelope (NE) as cells prepare to divide, and its reassembly as cells complete karyokinesis. The NEs that reform late in mitosis in each of the daughter cells are assembled from precursors that are released into the cytoplasm when the NE of the dividing cell disassembled. Because new protein synthesis is not required for NE reassembly, it is likely that disassembly and reassembly are controlled by reversible posttranslational modifications, such as protein phosphorylation. The best understood changes in NE components during mitosis are those of the lamins, the major components of the nuclear lamina. The lamins become highly phosphorylated during mitosis, and the filaments that comprise the nuclear lamina depolymerize into lamin dimers. The protein kinase activity of cyclin B/p34 cdc2 complexes is thought to play a major role in lamin phosphorylation.
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