Abstract
This chapter discusses isolations of mouse adenoviruses and pathological effects in mice. It also discusses its physical characteristics, serological reactions, and epidemiology and prevalence. Taxonomically, the adenoviruses are in the family Adenoviridae. Two genera have been established: (1) Mastadenovirus, which includes all mammalian adenoviruses, and (2) Aviadenovirus, into which the avian adenoviruses have been placed. A primary characteristic separating the two genera is the absence of any immunological cross-reactivity. Adenoviruses are classified and sub-classified primarily on the basis of molecular-physical and biological criteria. Some of these criteria include chemical composition, physiochemical properties, structure, and morphology. In addition, the site of replication, host range, pathogencity, transmission, and antigenic specificity are used. The present classification criteria of adenoviruses include cytopathogenicity, primarily for homologous cells in culture; lack of pathogenicity for distantly related species of animals; ether resistance and heat liability; and group- and type-specific antigens. In addition, they contain DNA and fit other structural and biophysical properties of adenoviruses, and they produce intranuclear inclusions. All adenoviruses have a classic cubic structure with a diameter of 65–80 nm.
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