Abstract
Protein dynamics plays a fundamental role in allosteric regulation. The chapter describes our studies on protein dynamics of human adult hemoglobin (Hb) using time-resolved resonance Raman spectroscopy. The observed spectral evolution showed detailed structural dynamics in the wide time range from picoseconds to submilliseconds to provide insights on the mechanism of Hb allostery. The results have contributed to a deeper understanding of the structural nature of protein motion and the relationship of dynamics to function. The functionally important protein dynamics and allosteric mechanism were discussed in terms of their relation to the nature of the high packing density of protein structures.
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