Abstract
Cerebral palsy is a syndrome diagnosed by a constellation of signs and symptoms with a plethora of potential etiologies, including genetic disruption. Animal models of cerebral palsy have primarily focused on a single etiology of inflicting a brain injury in immature animals, rather than the development of the symptoms diagnostic of this syndrome. The spa mouse has a genetic difference that results in the development of physical symptoms characteristic of humans with cerebral palsy. The predictability of symptoms and survival into adulthood makes the spa mouse well poised for studying both the longitudinal impact of hypertonia on the developing and aging central nervous system and musculoskeletal system, but also for investigating underlying physiologic changes in the central nervous system to identify targets for permanent improvement in symptoms.
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