Abstract
Histone modifications provide an important layer of regulation for chromatin functions and are critical for processes ranging from DNA replication to transcription, from cell-cycle regulation to differentiation, and from tissue specification during development to numerous diseases. Various histone modifications are also linked to DNA methylation and cell identity determination; hence they are now considered epigenetic markings. Distinct epigenetic changes, including changes in certain histone modifications, have been observed in various aged cells and tissues. However, are these changes simply marks of the consequences of aging, or are these changes a cause of aging? In this review, we summarize recent findings regarding epigenetic changes during aging and highlight evidence that suggest some of these changes are causal for aging and age-related diseases.
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