Abstract
Congenital cytomegalovirus (CMV) infection, the most common congenital viral infection worldwide, occurs in approximately 1% of infants. Most congenitally infected infants have no long-term sequelae related to CMV infection. Approximately 10% have sensorineural hearing loss or neurologic deficits, including cerebral palsy, epilepsy, and cognitive impairment. Because of the high prevalence of congenital CMV infection, CMV is the most common non-genetic cause of deafness in children and an important cause of permanent neurodevelopmental disabilities. Treatment with ganciclovir has modest beneficial effects on outcome; no vaccine is currently available to prevent congenital CMV infection.
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