Abstract
Publisher Summary This chapter describes the strategy and techniques used to study the expression of the rat sodium channel genes in different excitable tissues. The voltage-gated sodium channel is responsible for the generation of the action potential in nerve and muscle cells. Previous comparative studies of the functional properties of sodium channels have indicated that sodium channels in these two tissue types are very similar. Recent studies have concluded that sodium channels in nerve and muscle differ in significant ways. Investigators have shown that the sodium channels of skeletal muscle differ from the sodium channels in nerve and cardiac muscle in their affinities for the peptide sodium channel blocker, μ-conotoxin. mRNA purified from brain and muscle produces sodium channels that are both functionally and pharmacologically distinguishable in Xenopus oocyte membrane.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
