Chapter 14 Regulation of Ion Channels by Membrane Proteins

Abstract

Publisher Summary The cytoskeleton regulates ion channel function through integrated interactions with cytoskeleton-associated proteins and dynamic regulation of its own state. Two main roles for the cytoskeleton have been recognized in the regulation of ion channel function: (1) targeted distribution of ion channel proteins within specialized domains of the plasma membranes, and (2) modulation of ion channel activity. Cytoskeleton-dependent targeting and maintenance of ion channels at discrete plasma membrane sites, in turn, are regulated by catalytic processes, including protein phosphorylation by tyrosine kinases and protein kinase A (PKA). Thus, structural interactions between the cytoskeleton, cytoskeleton-associated proteins, and channel/receptor subunits determine the highly specialized distribution of ion channel proteins within domains of plasma membranes. Such site-directed distribution and anchoring of ion channels are required for proper intra- and intercellular signaling.