Abstract
The term ocular or intraocular lymphoma is generic, referring to various primary and secondary, B-cell or T-cell lymphomas that are found in the eye. Lymphoma biology and nomenclature had not advanced substantially until lymphocyte development was understood and laboratory recognition possible. The concept of primary intraocular lymphoma was questioned into the 1950s. In a time when light microscopy was the sole means of classifying lymphomas, reticulum cell sarcoma was one of the first lymphomas identified in the eye. This chapter outlines how advances in systemic lymphoma pathology have been applied to ophthalmic pathology. Primary vitreoretinal lymphoma, a high-grade B-cell malignancy, is the most common primary intraocular lymphoma. It is a subset of primary central nervous system lymphoma, which for reasons not fully understood, rarely develops extraneural metastases. The photograph gallery includes pathology of primary vitreoretinal lymphoma, intraocular involvement with extranodal marginal zone lymphoma, and secondary ocular involvement with systemic lymphomas.
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