Abstract
Publisher Summary In the brain, most interneurons are GABAergic. Glycinergic neurons are mainly localized in the spinal cord. Apart from the neurotransmittermediated signaling that occurs between interneurons and between interneurons and principal neurons, interneurons can be electrically coupled to each other via gap junctions. Powerful tools are being used to reveal the molecular organization of excitatory and inhibitory synapses and the various signaling pathways involved in these synapses. Recent developments in genomics and proteomics, gene knockout animal models, protein-protein interaction assays (such as yeast two-hybrid), and the production and application of novel specific antibodies in combination with immunofluorescence microscopy (confocal and two-photon) and electron microscopy Immunogold techniques are advancing at a very rapid pace our knowledge of the organization of the molecular machinery of chemical synapses.
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