Abstract
The human body relies on delicate feedback regulations to maintain homeostasis. Self-regulated drug delivery devices are capable of treating diseases by mimicking natural feedback-controlled regulation mechanisms. These devices can autonomously adjust their drug release profile in response to the fluctuations of different physiological indexes. With the assistance of advanced nanotechnology, mechanical/electronic fabrication, and artificial intelligence technology, self-regulated devices minimize delays in treatment and provide drugs released in precisely controlled amounts. Self-regulated devices with desirable drug release patterns represent state-of-the-art drug delivery and will provide more opportunities of personalized therapy for patients. In this book chapter, we survey the most popular strategies and techniques for fabricating and designing self-regulated drug delivery devices, summarize their applications in different diseases, and discuss their future prospects and potential challenges in clinical translation.
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