Chapter 13 - Photoacoustic Molecular Imaging: Principles and Practice

Abstract

Physically combining optical excitation and acoustic detection, photoacoustic (PA) tomography (PAT) has become increasingly popular in biomedical research. By analyzing the optical absorption signature of the target, PAT can image various endogenous and exogenous molecules with high resolution and high sensitivity. PAT's molecular sensitivity is uniquely accompanied by nonionizing radiation and deep penetration in biological tissues, which other high-resolution optical imaging modalities cannot yet achieve. In this chapter, we introduce the basic principles of PAT, summarize the most recent advancements in PA molecular imaging, and highlight the novel molecular probes for PAT. We also discuss the opportunities for future advancements.