Abstract
Stratified epithelium is regulated effectively in nature. The homeostasis of the normal membrane with its balance of proliferative gain and desquamative loss has been studied in animals, however inevitably with the ever-present constellation of unknown interventions by nervous system, blood vascular system, and endocrines. Stratified epithelium in culture is now available for new kinds of analysis. The interest is in the comparison of stratified epithelia from donors of different ages, for example bladders of newborn, young adult, and senescent rats. The normal development of many glandular epithelial organs involves the appearance of specialized progenitor cells as distinct structural aggregates, and the development of the organ by a sequence whereby the primary aggregate gives rise to secondary ones.
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