Abstract
Polymer conjugates, polymeric micelles, and liposomes are the basic formulations of nanomedicines for targeted delivery of drug and therapeutics, especially in the field of anticancer drug delivery, which is by taking advantage of enhanced permeability and retention (EPR) effect, the basic and core principle of targeted delivery of nanomedicine. The efficacy of anticancer nanomedicine depends on various pathophysiological and physicochemical factors such as particle size, shape, surface charge, in which selection of biomaterial is critically important. This chapter provides a solid rationale on EPR effect-based anticancer drug design and further discusses the technical details of major nano-formulations with an in-depth illustration of widely used polymers, that is, polyethylene glycol (PEG) and N-(2-hydroxy- propyl)methacrylamide (HPMA). The evolutionary development details and modifiable aspects of the representative polymers, PEG and HPMA, present an overall idea of polymeric conjugates and micelles design.
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