Abstract
Polymethyl methacrylate (PMMA) denture acrylic with antimicrobial effect is desired to prevent inflammation, candidiasis related to denture use, and also to improve oral hygiene status for denture wearer. As the antimicrobial capacities of metal nanoparticles have strongly influenced biomedical fields, this chapter deals with novel dental nanocomposites, the modified PMMA denture acrylic impregnated with noble metal nanoparticles, as an antifungal denture base that can be specified for clinical situations. Chemically reduced nanoparticles (Au, Pt, and Ag) under 10nm were combined to pristine PMMA respectively; nanocomposites were characterized by field emission scanning electron microscope and energy dispersive X-ray and atomic absorption spectroscopy. Antifungal effects were tested by fluorescence activated cell sorting and thermal gravimetric analysis, flexural strength, and color change were examined to evaluate the physicochemical property. Successful synthesis of nanocomposites with proper thermomechanical characters were produced and exhibited significant antiadherent effect against Candida albicans above 2.0% nanoparticles loaded when compared to pristine PMMA by no or extremely small amounts of ion eluted.
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