Abstract
Abstract GTP has been shown to be required for the translocation of nascent secretory and membrane proteins into the lumen of the endoplasmic reticulum (ER). To date, three components known to be involved in protein translocation, the 54 kDa sub-unit of SRP (SRP54) and both the alpha and the beta subunits of the SRP receptor (SRa and SRβ) have been shown to be GTPases. Here, we briefly review what is known about the role of GTP in protein translocation, and we present a speculative model that incorporates these findings.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
