Abstract
Nanomaterials have a huge potential to revolutionize the way in which we diagnose and treat disease as tools in biomedical research. This is due to their unique properties and characteristics accredited to the way in which they are fabricated, functionalized, and characterized. However, there is limited focus on the use of silica nanoparticles (SiNPs); in particular, the various methods in which they are used, the assessment of their stability and biosafety, and the strategies used to improve their biocompatibility. This chapter focuses on the potential use of SiNPs as diagnostic tools and therapeutic intervention modalities and provides an overview of the methods used to fabricate and characterize them. The chapter also highlights the strategies used to maximize the biocompatibility of SiNPs to improve their applicability and bioavailability, minimize their off-target localization and effects, and promote their guided delivery.
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