Abstract
Bipolar disorder (BD) is a psychiatric disorder frequently associated with cognitive impairment and reduction of lifespan. “Neuroprogression” is a term used to describe longitudinal and progressive alterations detectable in clinical and neurobiological variables in BD patients. The evolution of BD in all its forms begins in asymptomatic individuals with clinical features of risk, changing toward prodromes, and finally progressing into episodicity and chronicity. Neuroprogression in BD has been repeatedly associated with a significant decrease in overall functioning of individuals. Biomarkers involved in oxidative stress and inflammation are altered in patients at different stages of illness and have been hypothesized to play a key role in its progression. Moreover, the overlap of biochemical processes that occur in the brain in both BD and insulin resistance may lead to significant cognitive impairment. Overall, there is a strong correlation between biological progression and functional and cognitive impairment in the clinical course of BD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
